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Prof. ZHANG Cheng-Wu

Prof. ZHANG Cheng-Wu



Address: 5 Xin Mo Fan Road, Nanjing Tech University, Nanjing 210009, China

Research Interests

1. Utilizing cells, drosophila, mouse, as well as human derived induced pluripotent stem cells (iPS) as models to investigate the cellular and molecular mechanisms underlying pathogenesis of Parkinson's disease.

2. Taking advantage of Biochemistry and Nanotechnology to develop novel diagnostic and therapeutic strategy for Parkinson's disease.

Biographical Information

1998-2003: PhD degree in Physiology, Sichuan University, Sichuan China.

2003-2005: Post-Doc, Shantou Medical College, Shantou University.

2005-2009: Research Scientist, Singapore General Hospital, Singapore.

2009-2015: Senior Research Scientist, National Neuroscience Institute of Singapore.

2015--   : Professor; Institute of Advanced Materials, Nanjing Tech University.

Academic Achievements

Prof. ZHANG Cheng-Wu's research interest focuses on investigating the underlying mechanisms of Parkinson's disease with series of in vitro and in vivo models including primary cells, drosophila, mouse and human derived iPS. In recent years, he takes advantage of Biochemistry and Nanotechnology to develop novel diagnostic and therapeutic strategy for Parkinson's disease. He has chaired and completed one Singhealth Research Grant and one NMRC grant of Singapore. He published more than ten peer reviewed international papers including Nature Commnuications, Angewandte Chemie-International Edition, Stem Cells, Neurodegenerative Diseases, Frontiers in Aging Neuroscience, Investigative Ophthalmology &Visual Science, ect.



1. Cheng-Wu Zhang, Liting Hang, Tso-Pang Yao and Kah-Leong Lim. (2016) Parkin Regulation and Neurodegenerative Disorders. Frontiers in Aging Neuroscience, 7(article 248): 1-15

2. Cheng-Wu Zhang, Henry Basil Adeline, Bing-Han Chai, Eugenia T.E. Hong, Chee-Hoe Ng, Kah-Leong Lim. (2016) Pharmacological or genetic activation of Hsp70 protects against loss of parkin function. Neurodegenerative Diseases, 16 (Co-corresponding author)

3. Lin Li, Cheng-Wu Zhang, Jing-yan Ge, Linghui Qian, Bing-Han Chai, Qing Zhu, Jun-Seok Lee, Kah-Leong Lim, and Shao-Qin Yao. (2015) A Small-Molecular Probe for Selective Profiling and Imaging Monoamine Oxidase B Activities in Models of Parkinson's Disease. Angew. Chem. Int. Ed, 54, 10821-10825 (Co-first author)

4. Lin Li, Cheng-Wu Zhang, Grace Y.J. Chen, Biwei Zhu, Chou Chai, Qing-Hua Xu, Eng-King Tan, Qing Zhu, Kah-Leong Lim, Shao-Qin Yao. (2014) A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson's disease models. Nature Communications, 5: 3276 (Co-first author)  

5. Cheng-Wu Zhang, Qiang Lu, Siwei You, Ye Zhi, Henry K. Yip, Wutian Wu, Kwok-Fai So, Qi Cui. (2005) CNTF and BDNF have the same effects on the retinal ganglion cell survival but differential effects on the nitric oxide synthase expression soon after optic nerve injury. Investigative Ophthalmology & Visual Science, 46: 1497-1053.

6. Cheng-Wu Zhang, Heng Xiu Yan, Chuan Li, Yu Zheng. (2004) Possible involvement of the facial nucleus in the regulation of respiration in rats. Neuroscience Letters, 367: 283-288.

7. Jingyan Ge, Cheng-Wu Zhang, Xue Wen Ng, Bo Peng, Sijun Pan, Shubo Du, Danyang Wang, Lin Li, Kah-Leong Lim, Thorsten Wohland, and Shao Q.  (2016) Puromycin Analogues Capable of Multiplexed Imaging and Profiling of Protein Synthesis and Dynamics in Live Cells and Neurons. Angew. Chem. Int. Ed, 55: 1-6.

8. Kah Leong Lim, Cheng-Wu Zhang.(2013) Molecular events underlying parkinson's disease-an intervowen tasestry. Frontiers in Neurology. 4 (article 33): 1-10.

9. Yunhua Zhu, Cheng-wu Zhang, Li Lu, Oleg N. Demidov, Li Sun, Lan Yang, Dmitry V. Bulavin, Zhi-Cheng Xiao. (2009) Wip1 regulates the generation of new neural cells in adult olfactory bulb through p53 dependent cell cycle control. Stem Cells. 27(6): 1433-1442.

10. Li Lu, Xue Chen, Cheng-Wu Zhang, Yu-Lin Yang, Ya-Jun Wu, Li Sun, Li-Min Bai, Xiao-Song Gu, Sohail Ahmed, Gavin S. Dawe, Zhi-Cheng Xiao. (2008) Morphological and Functional Characterization of Predifferentiation of Oligodendrocyte-Like Cells from Human Bone Marrow Stromal Cells through Activation of F3/Notch Signaling in Mouse Retina. Stem Cells, 26: 580-590.


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