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弗吉尼亚州立联邦大学ANDREI V. BUDANOV博士学术报告
 添加时间:2016/03/01 发布: 管理员
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报告时间:2016年3月2日上午10:00

报告地点:科技创新大楼C501室

 

ANDREI V. BUDANOV
VIRGINIA COMMONWEALTH UNIVERSITY
DEPARTMENT OF HUMAN AND MOLECULAR GENETICS
MASSEY CANCER CENTER, GOODWIN BLDG., RM288
401 COLLEGE STREET, RICHMOND VA 23298
CELL: 1-858-822-8945 E-MAIL:
ABUDANOV@VCU.EDU
CITIZENSHIP: USA/RUSSIA

EDUCATION
________________________________________
2002  ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY, RUSSIAN ACADEMY OF SCIENCES, Moscow, Russia
Ph.D. in Molecular Biology                                     
Dissertation advisor: Dr. Peter M. Chumakov
Dissertation title: “Identification and characterization of a novel stress-responsive gene Hi95/Sestrin2”

1996  LOMONOSOV MOSCOW STATE UNIVERSITY, Moscow, Russia
BS/MS in Biochemistry and Virology


EMPLOYMENT
________________________________________
Dates                 Organization                                        Department                Supervisor                     Position
2013-now          Virginia Commonwealth University  Human and Molecular Genetics                     Assistant Professor
2011-2013         Virginia Commonwealth University  Neurosurgery/Biochemistry                           Assistant Professor
2008-2011         University of California San Diego  Pharmacology           prof. Michael Karin       Project Scientist
2004-2008         University of California San Diego  Pharmacology           prof. Michael Karin       Postdoctoral Fellow
2002-2004         The Cleveland Clinic Foundation     Molecular Genetics   prof. Peter Chumakov   Research Fellow
2000-2001         University of Illinois at Chicago      Molecular Biology     prof. Peter Chumakov   Visiting Scholar
1999                  University of Illinois at Chicago      Molecular Biology     prof. Andrei Gudkov     Visiting Scholar

 

AWARDS AND FELLOWSHIPS
________________________________________
2013-2018    NIH RO1 “Role of p53-inducible Sesn1 and Sesn2 genes in lung carcinogenesis”. CA172660 Budanov PI
2008-2013 NIH K99/R00 “Role of p53 and p53-inducible Sestrin1 and 2 genes in hepatocarcinogenesis”.  DK082080 Budanov PI
2005-2007  Tobacco Related Diseases Research Program, University of California, Postdoctoral           fellowship “Role of p53-regulated Sestrin genes in lung cancer”.
2004 The Cleveland Clinic Foundation William E. Lower Fellowship Thesis Prize for the Best Publication
2004   Oxygen Club California BASF, Young Investigator Award
2001  FEBS Forum of Young Scientists; Protein Structure-Function Trafficking and Signaling; 27th FEBS meeting, travel award
2000  FEBS-EMBO International Summer School Spetses; Molecular Mechanisms of Development and Disease, travel award
1999  International Union Against Cancer (UICC), Research Fellowship

 

PUBLICATIONS
________________________________________

1. Parmigiani A, and Budanov AV. (2016) Sensing the environment through Sestrins: implications for cellular metabolism. (Review). International Review of Cell and Molecular Biology (in press).

2. Ding B, Parmigiani A, Divakaruni AS, Murphy AN, and Budanov AV. (2016) Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Scientific Reports (in press).

3. Tsilioni I, Filippidis A, Kerenidi T, Budanov AV, Zarogiannis SG, and Gourgoulianis KI. (2016) Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells. Clinical Biochemistry Feb 11 epub ahead of print.

4. Ding B, Parmigiani A, Yang C and Budanov AV. Sesn2 controls cell death in response to proinflammatory cytokines in lung adenocarcinoma cells. Cell Cycle 14(20):3231-41

5. Budanov AV. (2015) SESTRINS regulate mTORC1 via RRAGs: The riddle of GATOR. Molecular and Cellular Oncology 2(3): e997113-1-3

6. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, and Budanov AV. (2014) Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Reports 9(4): 1281-91 PMID: 25457612 (cited 32 times)

7. Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, and Li J. (2014).Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic  heart. FASEBJ 29(2):408-17 PMID: 25366347 (cited 4 times)

8. Zhao B, Shah P, Budanov A, Qiang L, Ming M, Aplin A, Sims DM, and He YY. (2014). Sestrin2 sitively regulates AKT signaling and survival in human squamous cell carcinoma and melanoma cells. Journal of Biological Chemistry 289(52):35806-14 PMID: 25378405 (cited 2 times)

9. Lee JH*, Budanov AV* [*equal contribution], and Karin M. (2013). Sestrins orchestrate cellular metabolism to attenuate aging. (Review). Cell Metabolism 18(6): 792-801. PMID: 24055102 (cited 26 times)

10. Ben-Sahra I, Dirat B, Lauren K, Puissant A, Auberger P, Budanov A, Tanti JF, and Bost F. (2012). Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death and Differentiation 20(4):611-619. PMID: 23238567 (cited 28 times)

11. Lee JH*, Budanov AV* [*equal contribution], Talukdar S, Park EJ, Park HL, Park HV, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Violet B, Olefsky J, and Karin M. (2012). Maintenance of metabolic homeostasis by sestrin2 and sestrin3. Cell Metabolism 16(3):311-321. PMID: 22958918 (cited 45 times)

12. Budanov AV (2010). Stress-responsive Sestrins link p53 with redox regulation and mTOR   signaling. (Review). Antioxidant & Redox Signaling 15:1679-1690. PMID: 20712410 (cited 37 times)

13. Budanov AV, Lee JH, and Karin M. (2010). Stressin’ Sestrins take an aging fight. (Review). EMBO Molecular Medicine 2: 388-400. PMID: 20878915 (cited 46 times)

14. Lee JH, Budanov AV, Park EJ, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer E, Bier E, and Karin M (2009). Sestrin is a feedback inhibitor of mTOR that prevents age-related pathologies. Science 327: 1223-1228. PMID:20203043 (cited 161 times).

15. Budanov AV and Karin M. (2008). The p53-responsive Sestrin gene products inhibit mTOR signaling. Cell 134: 451-460. PMID: 18692468 (cited 432 times).
16.  Sablina AA*, Budanov AV* [equal contribution], Ilyinskaya GV, Agapova LS, Kravchenko JE, and Chumakov PM. (2005). The antioxidant function of the p53 tumor suppressor. Nature Medicine 11(12):1306-1313. PMID: 16286925 (cited 535 times).

17. Budanov AV, Sablina AA, Feinstein E, Koonin E, and Chumakov PM. (2004). Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD. Science 304:596-600. PMID: 15105503 (cited 393 times).

18. Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, and Feinstein E. (2002). Identification of a novel stress responsive gene Hi95 involved in regulation of cell viability. Oncogene 21: 6017-6031. PMID: 12203114 (cited 113 times).

19. Kochetkov DV, Ilyinskaya GV, Komarov PG, Strom E, Agapova LC, Ivanov AV, Budanov AV, Frolova EI, and Chumakov PM. (2007). Transcriptional inhibition of human papiloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53. Molecular Biology (Moscow) 41(3):515-523. PMID: 17685229 (cited 11 times).

20. Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, and Chumakov PM. (2005). Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors. Molecular Biology (Moscow) 39(2): 286-93. PMID: 15856952 (cited 12 times).

21. Razorenova OV, Ivanov AV, Budanov AV, and Chumakov PM. (2005). Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1. Gene 350(1):89-98. PMID: 15794924 (cited 21 times).

22. Gurova KV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Coen MB, and Gudkov AV. (2003). Cooperation of Two Mutant p53 Allels Contributes to Fas Resistance of Prostate Carcinoma Cells. Cancer Research 63:2905-2912. PMID: 12782597 (cited 39 times).

23. Shoshani T, Faerman A, Mett I, Zelin E, Tena T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E, Leshkovitz D, Einat P, Skaliter R, and Feinstein E. (2002). Identification of a Novel Hipoxia-Inducible Factor 1-responsible Gene RTP801, involved in Apoptosis. Molecular and Cellular Biology 7:2283-2293. PMID: 11884613 (cited 309 times).

24. Smirnov AS, Ruzov AS, Budanov AV, Prokhortchouk AV, Ivanov AV, and Prokhortchouk EB. (2001). High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells. Cell Death and Differentiation 8:621-630. PMID: 11536013 (cited 17 times).

25. Smirnov AS, Budanov AV, Ruzov AS, Ivanov AV, Prokhortchouk AV, Gnuchev NV, Prokhortchouk EB. (2000). A high constitutive level of NF-kappa B is necessary for viability of murine adenocarcinoma cells-possible role of p53. Molecular Biology (Moscow) 34(5):775-82. PMID:11033801 (cited 1 time)

26.  Neverova ME, Budanov AV, Adamskaya EI, Prasolov VS, and Kalinin ME. (2000). Construction  by using retrovirus vector of a recombinant with synthetic bradykinin gene for investigations of human gene expression in mammalian cells. Vest. Ross. Akad. Med. Nauk (Russia). 7:33-35. PMID: 10961146 (cited 2 times)

 

BOOK CHAPTERS
________________________________________
Budanov AV. The role of tumor suppressor p53 in the antioxidant defense and metabolism. Chapter in the book “p53 mutations and MDM2 overexpression and cancer”. (2014). Subcellular Biochemistry, Springer, 85:337-358. PMID: 25201203

Budanov AV. Sestrins Link Tumor Suppressors with the AMPK-TOR signaling network. (2012) Chapter in the book “Protein Phosphorylation in Human Health.” InTech

 

PRESENTATIONS
________________________________________
2015    Seminar talk, Wake Forest School of Medicine, Winston-Salem, NC
2014    Seminar talk, Skolkovo Institute of Technology, Skolkovo, Russia
2014    Seminar talk, Netherlands Cancer Institute (NKI), Amsterdam, Netherlands
2013    Seminar talk, Department of Biochemistry, School of Medicine, West Virginia University, Morgantown WV, USA
2013    Seminar talk, Center for Gene Regulation in Health and Diseases, Cleveland State University, Cleveland OH, USA
2013    Seminar talk, Department of Pharmacological Sciences, School of Medicine, Stony Brook University
2013    Invited speaker, V. Else Kr?ner-Fresenius Symposium on Adult Stem Cells in Aging, Diseases, and Cancer, Eisenach, Germany
2011    Seminar talk, Ulm University, Ulm, Germany
2011    Seminar talk, Department of Biochemistry, National University of Singapore, Singapore
2011    Seminar talk, College of Science, Koc University, Istamnul, Turkey
2009    Research talk, Edinburgh Cancer Research Center, Edinburgh, UK
2008    Research talk; 14th International p53 Workshop; Shanghai, China
2008    Cancer and Cell Biology Seminar Series Presentation, University of Cincinnati, Cincinnati OH, USA
2004    Research talk; Superfund Basic Research Program Seminar; University California San Diego, La Jolla CA, USA
2004    Research talk Symposium: p53 and Beyond; School of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia

 

TEACHING EXPERIENCE
________________________________________
1996-2013 Supervised undergraduate and graduate students in the Engelhardt Institute of Molecular Biology, The Cleveland Clinic, University California San Diego and Virginia Commonwealth University.
2013-now Lecture course for graduate and medical students at VCU: “Cancer”.
2013-now Lecture course for graduate students at VCU: “Cell Signaling”


MEETINGS ATTENDED
________________________________________
2015    AACR Meeting Integrating Metabolism and Tumor Biology, Vancouver, Canada
2014    AACR Meeting Molecular Origins of Lung Cancer, San Diego, CA
2013    V. Else Kr?ner-Fresenius Symposium on Adult Stem Cells in Aging, Diseases, and Cancer,  
            Eisenach, Germany
2013    AACR Annual Meeting 2013
2010    Microscopy: from genome scale to the single molecule, EMBO World Practical Course, Pretoria,  
            South Africa
2009    DNA microarray - analysis and applications, EMBO World Practical Courses, Tamil Nadu, India            
2009    Cancer Proteomics 2009: mechanistic insights, technological advances and   molecular medicine, Dublin, Ireland
2008    14th International p53 Workshop; Shanghai, China
2008    Keystone Symposia “Cancer and Microenvironment” (conference assistant)
2007    HHMI sponsored Lab Management Course; San Diego, CA
2004    12 th International p53 Workshop; Dunedin, New Zealand
2004    Cleveland Biology Symposium “Regulation of Nuclear Functions”; Cleveland, OH
2004    11th Annual meeting of the Oxygen Club of California, Santa Barbara, CA
2002    11th International p53 Workshop; Barcelona, Spain
2001    27th Meeting of the Federation European Biochemical Societies, Lisbon, Portugal


MEMBERSHIPS
________________________________________
American Association for Cancer Research (AACR)
Russian Biochemical Society

 

PATENTS
________________________________________
61/358,281 Michael Karin, Jun Hee Lee, and Andrei Budanov 2010
SESTRINS AND SESTRIN ANALOGS AS ANTI-AGING DRUGS AND AS THERAPIES FOR DEGENERATIVE DISEASES

 

REVIEWER
________________________________________
Ad hoc reviewer of grants for German Research Foundation (DFG), National Institute of Health Veteran Affair (USA), and VCU Massey Cancer Center pilot projects

 

REFERENCES
________________________________________
Michael Karin Ph.D., Professor of Pharmacology, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Dr., Leichtag Rm216, La Jolla, CA 92093 USA
Phone: 1-858-534-1361   Fax: 1-858-534-8158     Email:
karinoffice@ucsd.edu

 

Peter M. Chumakov Ph.D., M.D., Dr.Sci., Head of Laboratory of Cell Proliferation, Engelhardt Institute of Molecular Biology Russian Academy of Science, Moscow, Russia
Adjunct Staff Member, Department of Molecular Genetics, Lerner Research Institute/NE20, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195 USA
Phone: 1-216-444-9540    Fax:  1- 216-444-0512   Email:
chumakovpm@yahoo.com

 

Elena Feinstein Ph.D., M.D., Chief Scientific Officer, Quark Pharmaceuticals Inc. (former Quark Biotech Inc.) Ness Ziona 70400 Israel
Phone: 972-8-930-5113   Fax: 972-8-9406476        Email:
EFeinstein@quarkpharma.com

 

Andrei Ivanov Ph.D., Associated Professor, Department of Human and Molecular Genetics, School of  Medicine, Virginia Commonwealth University, Massey Cancer Center, 401 College St. Rm223, Richmond, VA 23298 USA
Phone: 1-804-628-4425    Fax: 1-804-827-1309      Email:
aivanov2@vcu.edu

 

 

 


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